Chronic pain and inflammation remain two of the most common reasons patients turn to medical cannabis. While research continues to evolve, consumer feedback, terpene science, and clinical evidence point toward specific strains that consistently deliver relief. The following list highlights some of the most recommended cultivars, the brands producing them, and where they can be found.
Harlequin – Balanced CBD for Daytime Relief
Harlequin is celebrated for its naturally high CBD content balanced with moderate THC. This ratio provides clear-headed relief without heavy intoxication, making it ideal for daytime use. Patients describe Harlequin as calming yet functional, often noting its ability to ease arthritis, migraines, and inflammatory discomfort. Cresco Labs grows Harlequin in several states, and shoppers can find it at Sunnyside dispensaries across Pennsylvania and Illinois. Its popularity lies in the combination of CBD’s anti-inflammatory effects and terpenes like myrcene and pinene that support relaxation.
ACDC – Gentle but Potent Anti-Inflammatory
ACDC, a phenotype of Cannatonic, has earned a reputation as one of the most effective CBD-dominant strains available. With THC levels often under 1% and CBD ratios climbing above 15%, it delivers therapeutic relief without a noticeable high. Consumers regularly recommend it for conditions like neuropathy and fibromyalgia. East Fork Cultivars in Oregon produces consistent ACDC flower and tinctures, with availability at Nectar, Kaleafa, and other regional dispensaries. Patients highlight ACDC for reducing inflammation, easing nerve pain, and providing calm focus throughout the day.
9 Pound Hammer – Nighttime Comfort
For those battling pain that interferes with sleep, 9 Pound Hammer is a reliable indica choice. Known for its heavy myrcene content, this strain delivers sedative, full-body relaxation. In Florida, Trulieve carries 9 Pound Hammer flower, while AYR dispensaries stock vape options. Reviews often describe it as “melting away” muscle tension and helping users drift into restorative rest, making it a favorite for evening relief.
Granddaddy Purple – Classic Muscle Relaxation
A long-standing staple, Granddaddy Purple (GDP) is widely recognized for easing muscle spasms, chronic pain, and stress. Its signature grape aroma and purple-hued buds are matched by effects that consumers describe as soothing and long-lasting. Florida’s Trulieve offers GDP under various brands, including Roll One and O.pen. Its wide availability and trusted reputation continue to make it a top recommendation for inflammation management.
GMO / Garlic Cookies – Strong Relief for Experienced Patients
For seasoned cannabis consumers, GMO—also called Garlic Cookies—is a powerhouse strain. Its high THC content and abundance of β-caryophyllene make it a heavy hitter against severe pain and inflammation. Shoppers can find GMO at Planet 13 dispensaries in Las Vegas and Orange County, where it appears under brands like Trendi and Coastal Sun. Consumers praise GMO for its deeply relaxing body effects, though many caution it is best reserved for nighttime use.
Why These Picks Stand Out
What unites these strains is their combination of cannabinoids and terpenes that target both pain perception and inflammatory response. CBD-forward options like Harlequin and ACDC are suitable for daytime function, while terpene-heavy indicas like 9 Pound Hammer, GDP, and GMO excel at nighttime relief. Together, they offer a versatile toolkit for patients seeking to manage chronic conditions.
Shopping Smart
Because dispensary menus change frequently, patients are encouraged to check live inventories online through retailers like Sunnyside, Trulieve, and Planet 13 before visiting. Looking at terpene profiles—especially for myrcene and β-caryophyllene—can help shoppers find strains tailored to their specific needs.